White-matter integrity on DTI and the pathologic staging of Alzheimer's disease

• DOI: 10.1016/j.neurobiolaging.2017.04.024
• Publication Date: 2017-05-04T03:31:26Z
• Authors: Kejal Kantarci; Melissa E. Murray; Christopher G. Sc...; Robert I. Reid; Scott A. Przybelski; Timothy Lesnick; Samantha M. Zuk; Mekala R. Raman; Matthew L. Senjem; Jeffrey L. Gunter; Bradley F. Boeve; David S. Knopman; Joseph E. Parisi; Ronald C. Petersen; Clifford R. Jack; Dennis W. Dickson
• Keywords: Cingulum (brain); Fornix

Pattern of diffusion tensor MRI (DTI) alterations were investigated in pathologically-staged Alzheimer's disease (AD) patients (n = 46). Patients with antemortem DTI studies and a range AD pathology at autopsy included. high neurofibrillary tangle (NFT) stage (Braak IV–VI) had significantly elevated mean diffusivity (MD) the crus fornix ventral cingulum tracts, precuneus, entorhinal white matter on voxel-based analysis after adjusting for age time from to death (p < 0.001). Higher MD lower fractional anisotropy tract, entorhinal, precuneus was associated higher Braak NFT clinical severity. There no differences among low (none sparse) (moderate frequent) β-amyloid neuritic plaque groups. The is involving medial temporal limbic connections parietal matter. This pattern abnormalities also