Instantaneous brain dynamics mapped to a continuous state space

• DOI: 10.1016/j.neuroimage.2017.08.042
• Publication Date: 2017-08-18T06:26:44Z
• Authors: Jacob C.W. Billings; Alessio Medda; Sadia Shakil; Xiaohong Shen; Amrit Kashyap; Shiyang Chen; Anzar Abbas; Xiaodi Zhang; Maysam Nezafati; Wen-Ju Pan; Gordon J. Berman; Shella D. Keilholz
• Keywords: Human Connectome Project

AbstractMeasures of whole-brain activity, from techniques such as functional Magnetic Resonance Imaging, provide a means to observe the brain’s dynamical operations. However, interpretation of whole-brain dynamics has been stymied by the inherently high-dimensional structure of brain activity. The present research addresses this challenge through a series of scale transformations in the spectral, spatial, and relational domains. Instantaneous multispectral dynamics are first developed from input data via a wavelet filter bank. Voxel-level signals are then projected onto a representative set of spatially independent components. The correlation distance over the instantaneous wavelet-ICA state vectors is a graph that may be embedded onto a lower-dimensional space to assist the interpretation of state-space dynamics. Applying this procedure to a large sample of resting and task data (acquired through the Human Connectome Project), we segment the empirical state space into a continuum of stimulus-dependent brain states. We also demonstrate that resting brain activity includes brain states that are very similar to those adopted during some tasks, as well as brain states that are distinct from experimentally-defined tasks. Back-projection of segmented brain states onto the brain’s surface reveals the patterns of brain activity that support each experimental state.