Progesterone shapes medial temporal lobe volume across the human menstrual cycle

• DOI: 10.1016/j.neuroimage.2020.117125
• Publication Date: 2020-07-04T06:22:00Z
• Authors: Caitlin M. Taylor; Laura Pritschet; Rosanna K. Olsen; Evan Layher; Tyler Santander; Scott T. Grafton; Emily G. Jacobs
• Keywords: Lobe

The rhythmic production of sex steroid hormones is a central feature the mammalian endocrine system. In rodents and nonhuman primates, are powerful regulators hippocampal subfield morphology. However, it remains unknown whether intrinsic fluctuations in alter morphology human brain. series dense-sampling studies, we used high-resolution imaging medial temporal lobe (MTL) to determine endogenous (Study 1) exogenous manipulation 2) MTL volume over time. Across menstrual cycle, progesterone were associated with volumetric changes CA2/3, entorhinal, perirhinal, parahippocampal cortex. Chronic suppression abolished these cycle-dependent effects led pronounced entorhinal cortex CA2/3 relative freely cycling conditions. No associations estradiol observed. These results establish progesterone's ability rapidly dynamically shape across cycle.