Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution

• DOI: 10.1016/j.neuroimage.2021.118639
• Publication Date: 2021-10-12T04:54:09Z
• Authors: Loreen Ruhm; Nikolai Avdievich; Theresia Ziegs; Armin M. Nagel; Henk M. De Feyter; Robin A. de Graaf; Anke Henning
• Keywords: Human brain; Temporal resolution

To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and fast chemical shift (CSI) sequence at an ultrahigh field strength B0 = 9.4 T. 2H temporal resolution 10 min enabled investigation glucose metabolism in healthy subjects.The study was performed double-tuned TxRx channels for 1H 8TxRx/2Rx Ernst angle 3D CSI nominal spatial 2.97 ml min.The [6,6'-2H2]-labeled due to TCA cycle could be made visible high metabolite images deuterated water, Glx over entire brain.X-nuclei MRSI as DMI can benefit from enabling higher resolutions.