Enhancing cortical network-level participation coefficient as a potential mechanism for transfer in cognitive training in aMCI

• DOI: 10.1016/j.neuroimage.2022.119124
• Publication Date: 2022-03-21T17:38:11Z
• Authors: Quanjing Chen; Adam Turnbull; Martin Cole; Zhengwu Zhang; Feng V. Lin
• Keywords: Cognitive Training

Effective cognitive training must improve cognition beyond the trained domain (show a transfer effect) and be applicable to dementia-risk populations, e.g., amnesic mild impairment (aMCI). Theories suggest should target processes that 1) show robust engagement, 2) are domain-general, 3) reflect long-lasting changes in brain organization. Brain regions connect many different networks (i.e., high participation coefficient; PC) known support integration. This capacity is relatively preserved aMCI, required across wide range of domains, trait-like. In 49 individuals with aMCI completed 6-week visual speed processing (VSOP) 28 active controls, enhancement PC was significantly more related working memory at global network levels VSOP compared particularly high-PC nodes. suggests enhancing integration may provide for developing effective training.