Post-stroke reorganization of transient brain activity characterizes deficits and recovery of cognitive functions

• DOI: 10.1016/j.neuroimage.2022.119201
• Publication Date: 2022-04-09T02:15:45Z
• Authors: Elvira Pirondini; Nawal Kinany; Cécile Le Sueur; Joseph C. Griffis; Gordon L. Shulman; Maurizio Corbetta; Dimitri Van De Ville
• Keywords: Stroke; Cingulum (brain)

Functional magnetic resonance imaging (fMRI) has been widely employed to study stroke pathophysiology. In particular, analyses of fMRI signals at rest were directed quantifying the impact on spatial features brain networks. However, networks have intrinsic time that were, so far, disregarded in these analyses. consequence, standard analysis failed capture temporal imbalance resulting from lesions, hence restricting their ability reveal interdependent pathological changes structural and network following stroke. Here, we longitudinally analyzed hemodynamic-informed transient activity a large cohort patients (n = 103) assess after Metrics extracted replicable within- between-individuals healthy participants, supporting robustness clinical applicability. While large-scale patterns preserved stroke, durations altered, with subjects exhibiting varied pattern longer shorter activations compared individuals. Specifically, showed duration lateral precentral gyrus anterior cingulum, occipital lobe cerebellum. These alterations associated white matter damage projection association pathways. Furthermore, they tied deficits specific behavioral domains as restoration dynamics paralleled recovery cognitive functions (attention, language memory), but was not significantly correlated motor recovery. findings underscore critical importance properties dissecting pathophysiology thus shedding new light potential time-resolved methods for analysis.