Neuroimaging of Parkinson's disease by quantitative susceptibility mapping

• DOI: 10.1016/j.neuroimage.2024.120547
• Publication Date: 2024-02-18T01:13:39Z
• Authors: Xiaojun Guan; Marta Lancione; Scott Ayton; Petr Dusek; Christian Langkammer; Minming Zhang
• Keywords: Quantitative Susceptibility Mapping; Pathogenesis

Parkinson's disease (PD) is a common neurodegenerative disease, and apart from few rare genetic causes, its pathogenesis remains largely unclear. Recent scientific interest has been captured by the involvement of iron biochemistry disruption homeostasis, particularly within brain regions specifically affected in PD. The advent Quantitative Susceptibility Mapping (QSM) enabled non-invasive quantification vivo MRI, which contributed to understanding iron-associated potential for development iron-based biomarkers This review elucidates biochemical underpinnings accumulation, details advancements iron-sensitive MRI technologies, discusses role QSM as biomarker deposition Despite considerable progress, several challenges impede clinical application after decade studies. initiation multi-site research warranted developing robust, interpretable, disease-specific monitoring PD progression.