Noninvasive Sacral Neuromodulation in Children and Adolescents: A Case-Control Study of Patients With Chronic Refractory Constipation

• DOI: 10.1016/j.neurom.2022.08.451
• Publication Date: 2022-10-05T00:07:05Z
• Authors: Sonja Diez; Annemarie Kirchga...; Dana Adam; Arne Füldner; Hanna Müller; Klaus E. Matzel; Manuel Besendörfer
• Keywords: Sacral nerve stimulation; Refractory (planetary science); Fecal Incontinence; Neuromodulation

In adult patients with chronic refractory constipation, invasive sacral neuromodulation (SNM) has been applied successfully. There is a need for less solutions while providing comparable therapeutic effects in children and adolescents. We present prospective, interventional case-control study on the application of noninvasive SNM.Patients constipation to conservative treatment were prospectively included from 2018 2021 randomized either SNM (SNM group: single current stimulation 24 h/d, frequency 15 Hz, pulse width 210 μs, intensity 1-10 mA) or conventional (controls: full range pharmacologic nonpharmacologic options). Treatment was conducted 12 weeks. collected specialized questionnaires quality-of-life analysis (KINDLR). Outcome variables defecation frequency, stool consistency, fecal incontinence (FI) episodes, abdominal pain.Analysis 28 31 controls (median age 7.0, 3-16 years). Overall responsiveness 86% group 39% control (p < 0.001). All outcome positively influenced by treatment. Defecation improved 46% 19% = 0.026), as did consistency 57% 26% 0.014). Fecal significantly reduced 76% (n 16/21 vs 42% [n 11/26], p 0.042). Quality life during (71.32 [baseline] 85.00 [after weeks], 0.001) confirmed positive influence compared (85.00 [SNM after weeks] 79.29 [controls 0.047).Outcome better than