Polymorphisms in the Drug Transporter Gene ABCB1 Predict Antidepressant Treatment Response in Depression

• DOI: 10.1016/j.neuron.2007.11.017
• Publication Date: 2008-01-25T17:46:51Z
• Authors: Manfred Uhr; Alina Tontsch; Christian Namendorf; Stephan Ripke; Susanne Lucae; Marcus Ising; Tatjana Dose; Martin Ebinger; Marcus Rosenhagen; Martin Kohli; Stefan Kloiber; Daria Salyakina; Thomas Bettecken; Michael Specht; Benno Pütz; Elisabeth B. Binder; Bertram Müller-My...; Florian Holsboer
• Keywords: Depression; Drug response

The clinical efficacy of a systemically administered drug acting on the central nervous system depends on its ability to pass the blood-brain barrier, which is regulated by transporter molecules such as ABCB1 (MDR1). Here we report that polymorphisms in the ABCB1 gene predict the response to antidepressant treatment in those depressed patients receiving drugs that have been identified as substrates of ABCB1 using abcb1ab double-knockout mice. Our results indicate that the combined consideration of both the medication's capacity to act as an ABCB1-transporter substrate and the patient's ABCB1 genotype are strong predictors for achieving a remission. This finding can be viewed as a further step into personalized antidepressant treatment.