The Leading Sense: Supramodal Control of Neurophysiological Context by Attention

• DOI: 10.1016/j.neuron.2009.10.014
• Publication Date: 2009-11-12T10:21:16Z
• Authors: Peter Lakatos; Monica N. O'Connell; Annamaria Barczak; Aimee Mills; Daniel C. Javitt; Charles E. Schroeder
• Keywords: Auditory Cortex; Male; Neurons; Periodicity; Neuroscience(all); Neuropsychological Tests; Acoustic Stimulation; Auditory Perception; Evoked Potentials, Auditory; Visual Perception; Animals; Evoked Potentials, Visual; Macaca; Attention; Theta Rhythm; SYSNEURO; Microelectrodes; Perceptual Masking; Photic Stimulation; Visual Cortex

Attending to a stimulus enhances its neuronal representation, even at the level of primary sensory cortex. Cross-modal modulation can similarly enhance a neuronal representation, and this process can also operate at the primary cortical level. Phase reset of ongoing neuronal oscillatory activity has been shown to be an important element of the underlying modulation of local cortical excitability in both cases. We investigated the influence of attention on oscillatory phase reset in primary auditory and visual cortices of macaques performing an intermodal selective attention task. In addition to responses "driven" by preferred modality stimuli, we noted that both preferred and nonpreferred modality stimuli could "modulate" local cortical excitability by phase reset of ongoing oscillatory activity, and that this effect was linked to their being attended. These findings outline a supramodal mechanism by which attention can control neurophysiological context, thus determining the representation of specific sensory content in primary sensory cortex.