Distinct Developmental Origins Manifest in the Specialized Encoding of Movement by Adult Neurons of the External Globus Pallidus

• DOI: 10.1016/j.neuron.2015.03.007
• Publication Date: 2015-04-05T18:24:53Z
• Authors: Paul D. Dodson; Joseph T. Larvin; James M. Duffell; Farid N. Garas; Natalie M. Doig; Nicoletta Kessaris; Ian C. Duguid; Rafal Bogacz; Simon J.B. Butt; Peter J. Magill
• Keywords: Ganglionic eminence

Transcriptional codes initiated during brain development are ultimately realized in adulthood as distinct cell types performing specialized roles behavior. Focusing on the mouse external globus pallidus (GPe), we demonstrate that potential contributions of two GABAergic GPe to voluntary action fated from early life be distinct. Prototypic neurons derive medial ganglionic eminence embryonic subpallium and express transcription factor Nkx2-1. These fire at high rates alert rest, encode movements through heterogeneous firing rate changes, with many decreasing their activity. In contrast, arkypallidal originate lateral/caudal eminences, FoxP2, low robust increases firing. We conclude developmental diversity positions prototypic fulfil behavior via disparate regulation GABA release onto different basal ganglia targets.