Subnetwork-Specific Homeostatic Plasticity in Mouse Visual Cortex In Vivo

• DOI: 10.1016/j.neuron.2015.05.010
• Publication Date: 2015-06-03T15:48:27Z
• Authors: Samuel J. Barnes; Rosanna P. Sammons; R. Irene Jacobsen; Jennifer Mackie; Georg B. Keller; Tara Keck
• Keywords: Homeostatic plasticity; Subnetwork; Homeostasis; Flatworm; Monocular deprivation

Homeostatic regulation has been shown to restore cortical activity in vivo following sensory deprivation, but it is unclear whether this recovery uniform across all cells or specific a subset of the network. To address issue, we used chronic calcium imaging behaving adult mice examine individual excitatory and inhibitory neurons same region layer 2/3 monocular visual cortex enucleation. We found that only fraction homeostatically recover after deprivation show no recovery. Prior did were more likely have significantly correlated with other recovering neurons, thus forming subnetwork neurons. These network level changes are accompanied by reduction synaptic inhibition onto suggesting both mechanisms important for homeostatic deprivation.