The Wound Microenvironment Reprograms Schwann Cells to Invasive Mesenchymal-like Cells to Drive Peripheral Nerve Regeneration

• DOI: 10.1016/j.neuron.2017.09.008
• Publication Date: 2017-09-27T20:33:39Z
• Authors: Melanie P. Clements; Elizabeth Byrne; Luis F. Camarillo...; Anne-Laure Cattin; Leila Zakka; Azhaar Ashraf; Jemima J. Burden; Sanjay Khadayate; Alison C. Lloyd; Samuel Marguerat; Simona Parrinello
• Keywords: Schwann cell; Reinnervation; Peripheral nerve injury

Schwann cell dedifferentiation from a myelinating to progenitor-like underlies the remarkable ability of peripheral nerves regenerate following injury. However, molecular identity differentiated and dedifferentiated states in vivo has been elusive. Here, we profiled cells acutely purified intact wound distal regions severed nerves. Our analysis reveals novel facets response, including acquisition mesenchymal traits Myc module. Furthermore, constitute different populations, with displaying increased character induced by localized TGFβ signaling. promotes invasion crosstalks Eph signaling via N-cadherin drive collective migration across wound. Consistently, Tgfbr2 deletion resulted misdirected delayed reinnervation. Thus, microenvironment is key determinant identity, it nerve repair through integration multiple concerted signals.Video AbstracteyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiIyZDRhMGVmOGMwNWE4NTMyZjY1NWE0MjQxYzVjMjNiZSIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjc5MzcwNjQwfQ.AfYB5fSBspHtjZFqBE_scYGtkZtRYZ3eTM3uJX6Y5qrXPhcmOvd84VzR_KgH-G3FfIixuQqXM0KpRHexmBAvMvDpnP6KR-xjAYXQCIzxl_He357fVckWVZ07xPbBHxTEWom0i_62fSDea--EMO6kzTrMoc8DPIu6lMgoKArduS7tgsQylewAvRi3y8JQRGQvcOHYKJORBz7mrdbjpW6NictvJjjTKZxQkU3G7QNfBGxO3FaGGIxXD7Stt7JTN8j8LtoH7Ft8gMXSQ0pGx1DYhUN3L3RzUYLtNg-tpJNOHchgNVIJLEDAhK5p0HT4LPkR5C24Ocr83RZ_yqAkBnCLVA(mp4, (12.16 MB) Download video