Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members

• DOI: 10.1016/j.neuron.2019.01.051
• Publication Date: 2019-02-26T10:35:59Z
• Authors: Gonzalo Ortiz-Álv...; Marie Daclin; Asm Shihavuddin; Pauline Lansade; Aurélien Fortoul; Marion Faucourt; Solène Clavreul; Maria-Eleni Lalioti; Stavros Taraviras; Simon Hippenmeyer; Jean Livet; Alice Meunier; Auguste Genovesio; Nathalie Spassky
• Keywords: Ependymal Cell; Lineage (genetic)

Adult neural stem cells and multiciliated ependymal are glial essential for neurological functions. Together, they make up the adult neurogenic niche. Using both high-throughput clonal analysis single-cell resolution of progenitor division patterns fate, we show that these two components niche lineally related: sister to cells, whereas most arise from terminal symmetric divisions lineage. Unexpectedly, found antagonist regulators DNA replication, GemC1 Geminin, can tune proportion cells. Our findings reveal controlled dynamic ontogeny identify Geminin family members as key initial pool