Chronic Infiltration of T Lymphocytes into the Brain in a Non-human Primate Model of Parkinson’s Disease

• DOI: 10.1016/j.neuroscience.2020.01.043
• Publication Date: 2020-02-07T08:23:18Z
• Authors: Jincheol Seo; Junghyung Park; Keonwoo Kim; Jinyoung Won; Hyeon-Gu Yeo; Yeung Bae Jin; Bon-Sang Koo; Kyung Seob Lim; Kang-Jin Jeong; Philyong Kang; Hwal-Yong Lee; Won Seok Choi; Seung Ho Baek; Chang-Yeop Jeon; Jung-Joo Hong; Jae-Won Huh; Young-Hyun Kim; Sang Je Park; Sun-Uk Kim; Dong-Seok Lee; Sang-Rae Lee; Youngjeon Lee
• Keywords: MPTP; Pathogenesis; Infiltration (HVAC); Neurotoxicity

Study of interactions between the nervous system and immunity offers insights into pathogenesis Parkinson's disease (PD) potential therapeutic strategies for neurodegenerative diseases. Studies on rodents have revealed regulatory mechanisms microglial activation T lymphocyte recruitment in PD. However, underlying chronic infiltration brain after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection a non-human primate (NHP) model PD remain unknown. This study aimed to investigate changes serum RANTES (regulated activation, normal cell expression secretion) analyze lymphocytes microglia NHPs at 48 weeks post-MPTP administration. We found selective local CD4+ CD8+ lymphocytes, loss dopaminergic neurons, dopamine transporter expression, normalization peripheral blood, altered morphology MPTP injection. confirms involvement MPTP-induced NHP models Additionally, we corroborated previous findings regarding lymphocyte-induced neurodegeneration. The our provide novel development preventive agents.