Adapting UK Biobank imaging for use in a routine memory clinic setting: The Oxford Brain Health Clinic

• DOI: 10.1016/j.nicl.2022.103273
• Publication Date: 2022-11-21T16:57:09Z
• Authors: Ludovica Griffanti; Grace Gillis; M. Clare O'Donoghue; Jasmine Blane; Pieter M. Pretorius; Robert Mitchell; Nicola Aikin; Karen Lindsay; Jon Campbell; Juliet Semple; Fidel Alfaro-Almagro; Stephen M. Smith; Karla L. Miller; Lola Martos; Vanessa Raymont; Clare E. Mackay
• Keywords: Memory clinic

The Oxford Brain Health Clinic (BHC) is a joint clinical-research service that provides memory clinic patients and clinicians access to high-quality assessments not routinely available, including brain MRI aligned with the UK Biobank imaging study (UKB). In this work we present how 1) adapted UKB acquisition protocol be suitable for patients, 2) modified analysis pipeline extract measures are in line radiology reports 3) explored alignment of from BHC largest world (ultimately 100,000 participants). Adaptations include dividing scan into core optional sequences (i.e., additional modalities) improve patients' tolerance assessment. We structural take account characteristics population (e.g., high amount white matter hyperintensities hippocampal atrophy). then compared derived phenotypes (IDPs) extracted scans visual ratings reports, non-imaging factors (age, cognition) reference distributions data. Of first 108 attendees (August 2020-November 2021), 92.5 % completed clinical scans, 88.0 consented use data research, 43.5 research sequences, demonstrating well tolerated. rates consent makes valuable real-world quality dataset captured service. Modified tissue-type segmentation lesion masking greatly improved grey volume estimation. CSF-masking marginally segmentation. IDPs were showed significant associations age cognitive performance, literature. Due difference between (age range 65-101 years, average 78.3 years) participants (44-82 64 years), on elderly healthy controls needed distributions. Current future aims integrate automated quantitative evaluate their utility.