Degradation of EEG microstates patterns in subjective cognitive decline and mild cognitive impairment: Early biomarkers along the Alzheimer’s Disease continuum?

• DOI: 10.1016/j.nicl.2023.103407
• Publication Date: 2023-04-19T08:46:54Z
• Authors: Michael Lassi; Carlo Fabbiani; Salvatore Mazzeo; Rachele Burali; Alberto Arturo Ve...; Giulia Giacomucci; Valentina Moschini; Carmen Morinelli; Filippo Emiliani; Maenia Scarpino; Silvia Bagnoli; Assunta Ingannato; Benedetta Nacmias; Sonia Padiglioni; Silvestro Micera; Sandro Sorbi; Antonello Grippo; Valentina Bessi; Alberto Mazzoni
• Keywords: Ministate; Cognitive Decline

Alzheimer's disease (AD) pathological changes may begin up to decades earlier than the appearance of first symptoms cognitive decline. Subjective decline (SCD) could be pre-clinical sign possible AD, which might followed by mild impairment (MCI), initial stage clinical However, neural correlates these prodromic stages are not completely clear yet. Recent studies suggest that EEG analysis tools characterizing cortical activity as a whole, such microstates and regions connectivity, support characterization SCD MCI conditions. Here we test this approach performing broad set analyses identify prominent markers differentiating (n = 57), 46) healthy control subjects (HC, n 19). We found salient differences were in temporal structure patterns, with being associated less complex sequences due altered transition probability, frequency duration canonic microstate C. Spectral content EEG, network spatial arrangement instead largely similar three groups. Interestingly, comparing properties different cerebrospinal fluid (CSF) biomarkers profiles, C displayed significant topography AD-like profile. These results show progression dementia degradation organization captured analysis, leads transitions between states. Overall, our paves way for use non-invasive recordings identification AD from its prodromal