Diminished baseline autonomic outflow in semantic dementia relates to left-lateralized insula atrophy

• DOI: 10.1016/j.nicl.2023.103522
• Publication Date: 2023-10-02T23:30:43Z
• Authors: Alice Y. Hua; Ashlin R.K. Roy; Eena L. Kosik; Nathaniel A. Morris; Tiffany E. Chow; Sladjana Lukic; Maxime Montembeault; Valentina Borghesani; Kyan Younes; Joel H. Kramer; William W. Seeley; David C. Perry; Zachary A. Miller; Howard J. Rosen; Bruce L. Miller; Katherine P. Rankin; Maria Luisa Gorno...; Virginia E. Sturm
• Keywords: Aging; Biological Psychology; Computer applications to medicine. Medical informatics; 150; R858-859.7; Neurodegenerative; Autonomic Nervous System; Clinical and health psychology; Electrodermal activity; Rare Diseases; Clinical Research; Behavioral and Social Science; Aphasia; Acquired Cognitive Impairment; 2.1 Biological and endogenous factors; Psychology; Humans; Autonomic nervous system; Aetiology; RC346-429; Alzheimer's Disease Related Dementias (ADRD); Heart rate variability; Neurosciences; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Semantic dementia; Regular Article; Magnetic Resonance Imaging; Temporal Lobe; 3. Good health; Brain Disorders; Frontal Lobe; Frontotemporal Dementia (FTD); Frontotemporal Dementia; Biological psychology; Dementia; Neurology. Diseases of the nervous system; Atrophy; Empathy

In semantic dementia (SD), asymmetric degeneration of the anterior temporal lobes is associated with loss of semantic knowledge and alterations in socioemotional behavior. There are two clinical variants of SD: semantic variant primary progressive aphasia (svPPA), which is characterized by predominant atrophy in the anterior temporal lobe and insula in the left hemisphere, and semantic behavioral variant frontotemporal dementia (sbvFTD), which is characterized by predominant atrophy in those structures in the right hemisphere. Previous studies of behavioral variant frontotemporal dementia, an associated clinical syndrome that targets the frontal lobes and anterior insula, have found impairments in baseline autonomic nervous system activity that correlate with left-lateralized frontotemporal atrophy patterns and disruptions in socioemotional functioning. Here, we evaluated whether there are similar impairments in resting autonomic nervous system activity in SD that also reflect left-lateralized atrophy and relate to diminished affiliative behavior. A total of 82 participants including 33 people with SD (20 svPPA and 13 sbvFTD) and 49 healthy older controls completed a laboratory-based assessment of respiratory sinus arrhythmia (RSA; a parasympathetic measure) and skin conductance level (SCL; a sympathetic measure) during a two-minute resting baseline period. Participants also underwent structural magnetic resonance imaging, and informants rated their current affiliative behavior on the Interpersonal Adjective Scale. Results indicated that baseline RSA and SCL were lower in SD than in healthy controls, with significant impairments present in both svPPA and sbvFTD. Voxel-based morphometry analyses revealed left-greater-than-right atrophy related to diminished parasympathetic and sympathetic outflow in SD. While left-lateralized atrophy in the mid-to-posterior insula correlated with lower RSA, left-lateralized atrophy in the ventral anterior insula correlated with lower SCL. In SD, lower baseline RSA, but not lower SCL, was associated with lower gregariousness/extraversion. Neither autonomic measure related to warmth/agreeableness, however. Through the assessment of baseline autonomic nervous system physiology, the present study contributes to expanding conceptualizations of the biological basis of socioemotional alterations in svPPA and sbvFTD.