Associations of resting-state perfusion and auditory verbal hallucinations with and without emotional content in schizophrenia

• DOI: 10.1016/j.nicl.2023.103527
• Publication Date: 2023-10-10T18:18:11Z
• Authors: Frauke Conring; Nicole Gangl; Melodie Derome; Roland Wiest; Andrea Federspiel; Sebastian Walther; Katharina Stegmayer
• Keywords: Ventromedial prefrontal cortex; Superior temporal gyrus

Auditory Verbal Hallucinations (AVH) are highly prevalent in patients with schizophrenia. AVH high emotional content lead to particularly poor functional outcome. Increasing evidence shows that associated alterations structure and function language memory related brain regions. However, neural correlates of remain unclear. In our study (n = 91), we resting state cerebral perfusion content, comparing four groups: 13), without 14), hallucinations 20) healthy controls 44). Patients presented increased within the amygdala ventromedial dorsomedial prefrontal cortex (vmPFC/ dmPFC) compared content. addition, any showed hyperperfusion anterior cingulate gyrus, vmPFC/dmPFC, right hippocampus, left pre- postcentral gyrus AVH. Our results indicate metabolic areas critical for processing emotions as key pathophysiology Particularly, may reflect even trigger AVH, while vmPFC/dmPFC cluster insufficient top-down regulation