Low-dose high-resolution TOF-PET using ionization-activated multi-state low-Z detector media

• DOI: 10.1016/j.nima.2021.165801
• Publication Date: 2021-09-14T15:10:28Z
• Authors: J.F. Shida; E. Spieglan; B.W. Adams; E. Angelico; K. Domurat-Sousa; A. Elagin; H.J. Frisch; P. La Riviere; A.H. Squires
• Keywords: Recoil

We propose PET scanners using low atomic number media that undergo a persistent local change of state along the paths Compton recoil electrons. Measurement individual scattering locations and angles, deposited energies, electron directions allows kinematical constraints 2-body process to perform statistical time-ordering scatterings, with high probability precisely identifying where gamma first interacted in detector. In these cases Line-of-Response is measured resolution, determined by underlying physics processes not detector segmentation. There are multiple such act through different mechanisms. As an example which quantum-mechanical molecular configuration, rather than thermodynamic, as bubble chamber, we present simulations two-state photoswitchable organic dye, `Switchillator', activated fluorescent-capable ionization The persistent, can be optically excited times image molecules. Energy resolution provided counting Location LOR implemented large-area time-of-flight MCP-PMT photodetectors single photon time tens ps sub-mm spatial resolution. Simulations indicate large reduction dose.