Protein energy wasting–based nutritional assessment predicts outcomes of acute ischemic stroke and solves the epidemiologic paradox

• DOI: 10.1016/j.nut.2021.111431
• Publication Date: 2021-07-24T23:16:50Z
• Authors: Li-Chun Ho; Hao-Kuang Wang; Lu-Ting Chiu; Hsi-Hao Wang; Yi-Che Lee; Shih-Yuan Hung; Yu Sun; Cheng-Yu Wei; Kai-Cheng Hsu; Yu-Wei Chen; Li-Ming Lien; Chung Y. Hsu
• Keywords: Stroke

Overweight and hyperlipidemia, the two established risk factors for acute ischemic stroke, are paradoxically associated with favorable outcomes. The paradox may be resolved by concept of protein energy wasting (PEW), in which total cholesterol level body mass index used as nutritional indexes predicting outcomes chronic kidney disease.Among 12 271 people stroke disease, 2086 were defined being at PEW-with a <22 kg/m2 plus either serum albumin <38 g/L or <4.14 mmol/L (160 mg/dL) without use lipid-lowering drugs-and all others control group. hazards PEW mortality functional evaluated using propensity score matching multivariate Cox regression analysis.Based on score, 2081 participants matched to same number non-PEW participants. was higher 3 mo (adjusted hazard ratio, 1.19; 95% confidence interval [CI], 1.02-1.42) 1 y 1.33; CI1.13-1.52). also poor (modified Rankin Scale >2) odds 1.32; CI, 1.08-1.61) 1.27; 1.03-1.56).According PEW-based assessment system, modest decrease levels suggests malnutrition is adverse stroke.