Dissolution-precipitation synthesis and cold sintering of mussel shells-derived hydroxyapatite and hydroxyapatite/chitosan composites for bone tissue engineering

• DOI: 10.1016/j.oceram.2023.100418
• Publication Date: 2023-07-28T01:47:28Z
• Authors: Anna Galotta; Kristaps Rubenis; Janis Locs; Vincenzo M. Sglavo
• Keywords: Biopolymer; Bioceramic

In the present work, seafood by-products and derivates were exploited as raw materials to produce nanocrystalline calcium phosphates-based composites in light of rising demand for waste recovery valorisation. Mussel shells transformed into hydroxyapatite by dissolution-precipitation synthesis at 45 °C, whereas chitosan from shrimp was introduced a reinforcing biopolymer hydroxyapatite/chitosan composites. The synthesised composite powders cold sintered room temperature under 1 GPa pressure 10 min. consolidated up ∼90% relative density characterized mechanically. By increasing polymer content wt%, flexural strength pellets increases ∼45 MPa ∼57 while hardness decreases ∼1.1 ∼0.8 GPa, thus better addressing mechanical properties cortical bone. Furthermore, proven be bioactive, this demonstrating their potential use bone tissue engineering applications.