Antioxidant enzymes, presbycusis, and ethnic variability

• DOI: 10.1016/j.otohns.2010.03.024
• Publication Date: 2010-07-20T09:06:20Z
• Authors: Anthony Bared; Xiaomei Ouyang; Simon Angeli; Li Lin Du; Kimberly Hoang; Denise Yan; Xue Zhong Liu
• Keywords: Presbycusis

A proposed mechanism for presbycusis is a significant increase in oxidative stress the cochlea. The enzymes glutathione S-transferase (GST) and N-acetyltransferase (NAT) are two classes of antioxidant active In this work, we sought to investigate association different polymorphisms GSTM1, GSTT1, NAT2 analyze whether ethnicity has an effect genotype-phenotype associations.Case-control study 134 DNA samples.University-based tertiary care center.Clinical, audiometric, testing 55 adults with 79 control patients normal hearing.The GSTM1 null genotype was present 77 percent white Hispanics 51 non-Hispanics (Fisher's exact test, 2-tail, P = 0.0262). GSTT1 34 60 subjects (P 0.0067, odds ratio [OR] 2.843, 95% confidence interval [95% CI] 1.379-5.860). more frequent subjects, i.e., 48 69 carried deletion 0.0198, OR 2.43, CI 1.163-5.067). NAT2*6A mutant among (60%) than (34%; 0.0086, 2.88, 1.355-6.141).We showed increased risk carrying NAT*6A allele. Subjects genotypes almost three times likely develop those wild type. prevalent non-Hispanics, but were equally represented groups.