Neural networks associated with quality of life in patients with Parkinson's disease

• DOI: 10.1016/j.parkreldis.2021.06.007
• Publication Date: 2021-06-17T11:46:44Z
• Authors: Tomohito Nakano; Yuta Kajiyama; Gajanan S. Revankar; Ryota Hashimoto; Yoshiyuki Watanabe; Haruhiko Kishima; Manabu Ikeda; Masahito Mihara; Hideki Mochizuki; Noriaki Hattori
• Keywords: Cerebral Cortex; Male; Parkinson Disease; Fear; Middle Aged; Gyrus Cinguli; Magnetic Resonance Imaging; Severity of Illness Index; Temporal Lobe; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Parietal Lobe; Activities of Daily Living; Connectome; Quality of Life; Humans; Accidental Falls; Female; Nerve Net; Gait Disorders, Neurologic; Aged

The neural underpinnings of health-related quality of life in Parkinson's disease remain unclear. This study was conducted to unravel which motor and non-motor symptoms in Parkinson's disease influence health-related quality of life and reveal neural networks most likely linked to it.Comprehensive clinical assessments were conducted for 247 Parkinson's disease patients and image analyses were performed for 181 patients. Clinical scores commonly used to assess various symptoms related to health-related quality of life were investigated. Factor and resting-state functional magnetic resonance imaging analyses were reviewed to reveal health-related quality of life-associated brain networks.The Spearman's rank correlation coefficient for the Parkinson's disease Questionnaire-39 summary index was high in the Activities-specific Balance Confidence Scale, Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale part 2, Freezing of Gait Questionnaire, and Self-reported Autonomic Symptoms in Parkinson's disease. Multiple regression and Random Forest regression analyses indicated that health-related quality of life-associated factors were Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale part 1, Depression Rating Scales, and the above-mentioned scales. The resting-state functional magnetic resonance imaging analysis revealed decreased functional connectivity between the anterior cingulate cortex and right temporo-parietal junction as health-related quality of life worsened.Fear of falling, daily living activities, gait freezing, and autonomic dysfunction have notable effects on health-related quality of life in Parkinson's disease. Brain networks consisting of the anterior cingulate cortex and temporo-parietal junction may be associated with the emotion-related and social factors of health-related quality of life in Parkinson's disease.