The 5-HT7 receptor antagonist SB 269970 ameliorates maternal fluoxetine exposure-induced impairment of synaptic plasticity in the prefrontal cortex of the offspring female mice

• DOI: 10.1016/j.pbb.2024.173779
• Publication Date: 2024-04-28T21:45:59Z
• Authors: Bartosz Bobula; Magdalena Kusek; Grzegorz Hess
• Keywords: 5-HT7 receptor

The use of a selective serotonin reuptake inhibitor fluoxetine in depression during pregnancy and the postpartum period might increase risk affective disorders cognitive symptoms progeny. In animal models, maternal exposure to throughout gestation lactation negatively affects behavior offspring. Little is known about effects on synaptic transmission plasticity offspring cerebral cortex. During C57BL/6J mouse dams received (7.5 mg/kg/day) with drinking water. Female mice intraperitoneal injections 5-HT