Progesterone improves motor coordination impairments caused by postnatal hypoxic-ischemic brain insult in neonatal male rats

• DOI: 10.1016/j.pedneo.2024.03.012
• Publication Date: 2024-08-23T03:21:39Z
• Authors: Hongying Piao; Hiroshi Ishikawa; Tatsuya Kobayashi; Keiko Kitajo; Atsushi Yamaguchi; Kaori Koga; Makio Shozu
• Keywords: Insult; Motor coordination; Brain damage

Hypoxic-ischemic (HI) insult in infants induces brain injury and results motor coordination impairments associated with cerebral palsy; however, preventive measures for HI preterm remain unclear. We investigated the impact of progesterone (P4) a rat model that mimics infants.