Glucagon does not directly stimulate pituitary secretion of ACTH, GH or copeptin

• DOI: 10.1016/j.peptides.2024.171213
• Publication Date: 2024-04-10T06:48:47Z
• Authors: Ida Stangerup; Sasha A.S. Kjeldsen; Michael M. Richter; Nicole J. Jensen; Jørgen Rungby; Steen Bendix Haug...; Birgitte Georg; Jens Hannibal; Kjeld Møllgård; Nicolai J. Wewer ...; Camilla Bjørnbak ...
• Keywords: Copeptin; Glucagon receptor

Glucagon is best known for its contribution to glucose regulation through activation of the glucagon receptor (GCGR), primarily located in liver. However, glucagon's impact on other organs may also contribute potent effects health and disease. Given that glucagon-based medicine entering arena anti-obesity drugs, elucidating extrahepatic actions are increased importance. It has been reported stimulate secretion arginine-vasopressin (AVP)/copeptin, growth hormone (GH) adrenocorticotrophic (ACTH) from pituitary gland. Nevertheless, mechanisms whether GCGR present human unknown. In this study we found intravenous administration 0.2 mg 14 healthy subjects was not associated with increases plasma concentrations copeptin, GH, ACTH or cortisol over a 120-min period. immunoreactivity anterior but cells containing GH ACTH. Collectively, directly AVP/copeptin humans instead be involved yet unidentified functions.