Chronic immune thrombocytopenic purpura in children overview of 60 patients

• DOI: 10.1016/j.phoj.2016.04.002
• Publication Date: 2016-05-13T23:01:20Z
• Authors: Ahmed Hatem Sabhan; Mazin Faisal Al-J...; Hasanein Habeeb G...; Wisam Majeed Abed; Salma Abbas Al-Hadad
• Keywords: Thrombocytopenic purpura

A small percentage of children with Immune thrombocytopenic purpura (ITP) suffer from a clinically significant disease severe thrombocytopenia that requires intervention. Treatment for these presents challenge as there are few known therapies offer long-term remission, and all have side effects toxicities. To evaluate the variety treatment modalities on clinical course, long outcomes in chronic ITP. study involved 60 ITP who were referred to Hemato-Oncology unit/Children's Welfare Teaching Hospital/Medical City/Baghdad. patients included steroid, Intravenous Immunoglobulins, Anti D immunoglobulin, 6-Mercaptopurine, Rituximab splenectomy. The Period data collection analysis was May 2009 2011. most common presenting symptom skin bleeding, seen 42 (70%) patients. Thirty-four received one or more courses steroids. Complete response achieved 7 (20.5%) while no 12 (35.2%) patients, immunoglobulin used 5 only (16%) exhibited good response. Immunoglobulin six patients; (8.3%) patient got Twelve 6-mercaptopurine, had partial Six Rituximab; three (50%) underwent splenectomy; noted 5/6 (83.3%) At end study; complete 13 (22.4%) 19 (31.6%), 28 (46.7%) Splenectomy is effective modality when treating whose symptoms severe.