Intensity-based readout of resonant-waveguide grating biosensors: Systems and nanostructures

• DOI: 10.1016/j.photonics.2017.07.003
• Publication Date: 2017-07-30T00:15:57Z
• Authors: Moritz Paulsen; Sabrina Jahns; Martina Gerken
• Keywords: Aperiodic graph; Waveguide; SIGNAL (programming language)

Resonant waveguide gratings (RWG) − also called photonic crystal slabs (PCS) have been established as reliable optical transducers for label-free biochemical assays well cell-based assays. Current readout systems are based on mechanical scanning and spectrometric measurements with system sizes suitable laboratory equipment. Here, we review recent progress in compact intensity-based point-of-care (POC) applications. We briefly introduce PCSs sensitive different approaches systems. Photometric realized a simple combination of light source photodetector. Recently 96-channel, both interaction analyses cellular was presented employing the intensity change near cut-off mode. As an alternative multiparametric detection, camera imaging detection has implemented. A portable, camera-based size 13 cm × 4.9 3.5 six areas RWG surface area 11 mm 7 demonstrated parallel protein binding kinetics. The signal-to-noise ratio this corresponds to limit 168 M (24 ng/ml). To further improve advanced nanostructure designs investigated RWGs. results multiperiodic deterministic aperiodic nanostructures presented. These allow design number wavelengths resonances. In context they particularly interesting realization multi-LED trends suggest that disposable test chips functional may reach market future.