Contribution of Sub-Saharan African medicinal plants to cancer research: Scientific basis 2013–2023

• DOI: 10.1016/j.phrs.2024.107138
• Publication Date: 2024-03-11T09:06:01Z
• Authors: Marc D.W. Adico; Bagora Bayala; Julio Bunay; Silvère Baron; Jacques Simpore; Jean-Marc A. Loba...
• Keywords: Anticancer drug

Cancer incidence and mortality rates are increasing worldwide. treatment remains a real challenge for African countries, especially in sub-Saharan Africa where funding resources very limited. High costs, side effects drug resistance associated with cancer have encouraged scientists to invest research into new herbal drugs. In order identify potential anticancer plants development, this review aims collect summarize activities (in vitro/in vivo) molecular mechanisms of medicinal plant extracts against cell lines. Scientific databases such as ScienceDirect, Google Scholar PubMed were used search articles published from January 2013 May 2023 on Africa. The data analyzed highlight the cytotoxicity action these listed plants. A total 85 papers covering 204 species selected review. These come 57 families, most dominant being family Amaryllidaceae (16), Fabaceae (14), Annonaceae (10), Asteraceae (10). Plant exert their activity mainly by inducing apoptosis stopping cycle cells. Several therefore strong original phytochemicals. Chemoproteomics, multi-omics, genetic editing technology (CRISPR/Cas9), combined therapies artificial intelligence tools cutting edge emerging technologies that facilitate discovery structural understanding molecules plants, reveal direct targets, explore therapeutic uses bases.