The impact of combination therapy of Croton membranaceus and finasteride on benign prostatic hyperplasia (BHP) histo-morphology

• DOI: 10.1016/j.phyplu.2024.100543
• Publication Date: 2024-03-11T10:19:55Z
• Authors: George A. Asare; Bernice Asiedu; Vivash Naidoo; Josephine Ablakwa; Samuel Adjei; Brodrick Amoah; Richard Obeng-Kye...; Lesetja Motadi; Mokbul Hossain; Munmun Parveen; Antora Akter; Mahmudul Alam; Mohammed Habibur ...
• Keywords: Tamsulosin; Testosterone propionate; Group B; Group A

Benign Prostatic hyperplasia (BPH) is one of the age-related conditions that reduce quality life in aging men. Treatment modalities range from surgical, use allopathic drugs, to phytotherapy. Allopathic drugs such as Finasteride and Tamsulosin are often considered have adverse side effects reduced libido erectile dysfunction. In some countries finasteride recommended for BPH although prefer Croton membranaceus (CM). However, indigenes combine two. The study therefore sought determine impact this combination therapy CM on histomorphologically. Thirty-five (35) male Sprague Dawley rats (200-250g) made up following groups were established with 5 each group: Group 1, served control group; group 2 (model group); 3 (0.5 mg/kg.b.wt Finasteride- positive control); 4 [30 mg/kg b.wt. (low dose)]; [300 (high 6 (30 plus 0.5 mg/kg. Finasteride); 7 (300 Finasteride). Groups 2-7 castrated, allowed rest days BPH-induced by administering testosterone propionate subcutaneously daily 28 days. administered oral gavage. prostate its accessory organs weighed examined histologically. untreated group) fibromuscular stroma showed typical characteristic high epithelial folds apparent hyperplasia. increased rate apoptosis progressive decrease cell size. At lower dose CM, not enough apoptotic areas observed. multiple layers acinar epithelia noticed. higher few cells seen acini fluid reduction. Low led level reduction accompanied fat droplets reactive infiltration. a papillary fronds protruded into acini. appeared coagulated. treatment did any hepatorenal effect, nor it change PSA significantly. No overt advantage was therapy, doses tandem may be advisable. there good tolerability.