Zingiber officinale Roscoe extract improves nigrostriatal dopaminergic activity in rotenone-induced Parkinsonian mice: Implication of COX-2/TNF-α/IL-6 and antioxidant enzyme crosstalk in the immunoinflammatory responses

• DOI: 10.1016/j.phyplu.2024.100610
• Publication Date: 2024-08-08T01:27:29Z
• Authors: Olusegun G. Adebayo; Benneth Ben-Azu; Egwonor Akpofure; Emmanuel U. Modo; Iheangwam Pauline...; Joseph Igbo Enya; Favor Akpakpan Ud...; Benjamin Oritsemu...; Emmanuel O. Chidebe; Joseph Chimezie; Noah A. Omeiza; Jerome Ndudi Asiwe; Silver Isosiya Da...; Samuel A. Onasanwo
• Keywords: Rotenone; Zingiber officinale; MPTP; Nigrostriatal pathway

Parkinson's disease (PD) is a chronic neurodegenerative that occurs progressively with time. Current PD treatments are symptomatic moderate effects on striatal dopamine release. Previously, the ethnomedicinal benefits of Zingiber officinale Roscoe have been demonstrated to possess broad range pharmacological benefits, but no single data its effect against nigrostriatal degeneration in model has reported. Proactive neuroprotective and pharmacotherapeutic approaches asymptomatic needed prevent progression maintain appropriate population dopaminergic neurons. can only elevate levels. Hence, objective study elucidate neurorestorative properties methanol extract (MEZO) implicated by immunoinflammatory responses rotenone-challenged mice model. Male Swiss were injected rotenone (2.5 mg/kg) intraperitoneally induce symptoms 30 minutes prior MEZO (50 100 LD-CD (10 oral treatment for 28 days. Motor/neuromuscular behavior, dopamine, acetylcholinesterase (AChE), tyrosine hydroxylase (TH), α-synuclein (α-syn), cyclooxygenase-2 (COX-2), oxidative stress markers, inflammatory cytokines, histopathology evaluated. Our showed attenuated sensorimotor neuromuscular incompetence up-regulating expression TH protein release maintaining AChE enzyme mice. We observed prevented formation Lewis bodies (LBs) inhibiting aggregation α-Syn proteins, decreasing pro-oxidant pro-inflammatory mediators (COX-2) expression, increasing glutathione enzymes, moderately abated loss neurons dose-dependent These findings exhibited potential management PD.