Zaprinast, a phosphodiesterase type-5 inhibitor, alters paced mating behavior in female rats
Male
Time Factors
Maximum Tolerated Dose
Purinones
Phosphodiesterase Inhibitors
Ovariectomy
Estrogens
Mating Preference, Animal
Rats
Sexual Behavior, Animal
03 medical and health sciences
0302 clinical medicine
Reaction Time
Animals
Female
Rats, Long-Evans
Progestins
Progesterone
DOI:
10.1016/j.physbeh.2008.10.013
Publication Date:
2008-10-30T08:08:42Z
AUTHORS (3)
ABSTRACT
Nitric oxide (NO) is the primary mediator of blood flow in female genital tissues and drugs that enhance the activity of nitric oxide, such as phosphodiesterase type-5 (PDE-5) inhibitors, increase vaginal blood flow in anesthetized rats. The goal of the present study was to test the effects of one PDE-5 inhibitor, zaprinast, on the display of sexual behaviors in gonadectomized, estrogen- and progesterone-treated female rats. Experiment 1 demonstrates that zaprinast alters paced mating behavior by lengthening the contact-return latency to ejaculation; there is a significant relationship between dose of zaprinast (range 1.5-6 mg/kg) and contact-return latency to ejaculation. Experiment 2 illustrates that zaprinast has no effect on preference for an intact male as measured in a No Contact partner preference test. Rats receiving zaprinast tend to exhibit reduced locomotor activity in both experiments. Collectively, these findings demonstrate that modulation of the NO-cGMP pathway using a PDE-5 inhibitor alters the display of paced mating behaviors in rats.
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