Early onset of obesity induces reproductive deficits in female rats

• DOI: 10.1016/j.physbeh.2011.12.002
• Publication Date: 2011-12-12T16:36:55Z
• Authors: Sara C. Sagae; Everson Ferreira ...; Maria L. Bonfleur; Emerielle C. Vanzela; Patrícia Zacharias; Camila Lubaczeuski; Celso R. Franci; Gilberto L. Sanvitto
• Keywords: Cafeteria

The incidence of obesity is increasing rapidly all over the world and results in numerous health detriments, including disruptions reproduction. However, mechanisms by which excess body fat interferes with reproductive functions are still not fully understood. After weaning, female rats were treated a cafeteria diet or chow (control group). Biometric metabolic parameters evaluated adulthood. Reproductive parameters, estradiol, progesterone, LH prolactin during proestrus afternoon, sexual behavior, ovulation rates histological analysis ovaries also evaluated. Cafeteria was able to induce pad weight, resulted increased levels triglycerides, total cholesterol, LDL induced insulin resistance. negatively affected reproduction reducing number oocytes preantral follicles, as well thickness follicular layer. Obese females did show preovulatory progesterone surges, though plasma estradiol showed surges similar control rats. Nevertheless, receptiveness altered diet. Taken together, our suggest that administered from weaning age reduce capability adult rats, indicating this model can be used better understand underlying dysfunction obese subjects.