Sex differences in glucocorticoids-induced anabolic effects in rats

• DOI: 10.1016/j.physbeh.2019.112587
• Publication Date: 2019-06-24T15:57:38Z
• Authors: Larissa Rugila S....; Camila F. de Souza; Geisielle Fernand...; Andressa B. Martins; Renan Nascimento ...; Fábio Goulart de ...; Cristiane Mota Leite; Dimas A.M. Zaia; Cassia Thaïs B.V....; Ernane Torres Uchoa
• Keywords: Corticosterone

Glucocorticoids (GC) increase food intake and body weight in humans rodents chronic stress GC treatment-induced enhancement of the plasma concentration lead to obesity metabolic changes. In response hypercaloric treatment, males were shown be more susceptible than females, demonstrating that sex differences may affect energy homeostasis. The objective current study was evaluate effects prolonged (28 days) treatment with dexamethasone or corticosterone on gain intact rats, both male female. Also examined Lee index, weights area adipocytes retroperitoneal perigonadal+perirenal adipose tissues, glucose tolerance test (GTT) concentrations free fatty acids, cholesterol triglycerides. Treatment able weight, intake, tissue males. Prolonged also stimulated addition, it induced an perirenal+perigonadal higher glycemia after GTT these animals, without changes index parameters treatments. No parameter changed by female rats. Thus, can concluded rats are anabolic glucocorticoids responses due protective circulating estrogens and/or difference between females expression/activity corticosteroids receptors.