Sutherlandiosides E−K: Further cycloartane glycosides from Sutherlandia frutescens

• DOI: 10.1016/j.phytol.2024.03.012
• Publication Date: 2024-03-29T20:00:26Z
• Authors: Billy T. Tchegnit...; Mookho S. Lerata; Denzil R. Beukes; Edith M. Antunes
• Keywords: Chemical structure; Specific rotation; Cancer cell lines

A further chemical investigation of the butanol extract leaves from South African medicinal plant Sutherlandia frutescens led to isolation eight previously unreported saponins (1−8), together with known sutherlandiosides A−D. Their structures were established by spectroscopic (1D and 2D NMR) analyses, CD, optical rotation, mass spectrometry, as well conversions. The isolates screened for their cytotoxic activity against MCF-7 human breast cancer cell line, although no significant was observed. In addition chemophenetic markers this genus, i.e. cycloartane glycosides, present work also reports on first an oleanan-type saponin forming important fingerprint composition plant.