Urinary and serum levels of high mobility group box 1

• DOI: 10.1016/j.plabm.2023.e00327
• Publication Date: 2023-07-12T01:28:36Z
• Authors: Toshihiko Nakamura; Atsushi Yoshida; Daisuke Hatanaka; Michiko Kusakari; Hidehiro Takahashi; Shinji Katsuragi; Shingo Yamada; Takashi Kamohara
• Keywords: Serum; Medicine (General); Chemistry; R5-920; Short Communication; Neonates; ELISA; Urinary; Acetylated truncated HMGB-1; Hypoxic ischemic encephalopathy; QD1-999; 3. Good health

High mobility group box 1 (HMGB-1) has been extensively studied in adults and to a certain extent neonates as well. Clinical examination of neonates, especially unwell soon after birth, should be minimally invasive.This study aimed investigate whether the urinary HMGB-1 level is comparable serum neonates.In all, 87 (37.5 ± 2.9 weeks gestation mean birth weight 2588 649 g) were enrolled. Of these, 53 males 34 females. The umbilical cord blood first or second spontaneous voiding urine samples stored, was measured.HMGB-1 detected all samples. In these samples, we found acetylated may devoid nine residues at N-terminal amino acid sequence. There significant correlation between (r = 0.73, p < 0.001). Urinary HMGB1 levels fetal neonatal asphyxia significantly higher than those healthy controls (p 0.09).Urinary excretion one metabolic pathways HMGB-1. early period.