TAM and TIM receptors mRNA expression in Zika virus infected placentas

• DOI: 10.1016/j.placenta.2020.09.062
• Publication Date: 2020-09-28T18:25:18Z
• Authors: Guilherme M. Nobrega; Ana Paula Samogim; Pierina L. Parise; Emanuella M. Venc...; José Paulo S. Guida; Rodolfo R. Japecanga; Mariene R. Amorim; Daniel A. Toledo-...; Julia Forato; Sílvio R. Consonni; Maria Laura Costa; José Luiz Proenca...; Eliana Amaral; Helaine Maria Bes...; Carolina C. Ribei...; Roseli Calil; João Renato Benni...; Giuliane Jesus Lajos; Albina Altemani; Maria Luiza Moretti; Mariangela Ribeir...; Márcia Teixeira G...; Rodrigo Nogueira ...; Marcos Tadeu Nola...; Ana Carolina Coan; Maria Francisca C...; Andrea Paula Brun...; André Ricardo Rib...; Marco Aurélio Ram...; Rodrigo Ramos Cat...; Fábio Trindade Ma...; Clarice Weis Arns; Aline Vieira; Gabriela Fabiano ...; Karina Bispo dos ...; Mariene Ribeiro A...; Matheus Cavalheir...; Stéfanie Primon M...
• Keywords: Zika Virus

To investigate the role of TYRO3, AXL and TIM1 receptors in the Zika virus (ZIKV) cycle, we determined their mRNA expression in different placental sites of ZIKV infected tissue during pregnancy. Unexpectedly, the ZIKV infection was not related with mRNA upregulation of these receptors or changes in expression of type I and III interferons in different placental sites. Instead, a decrease of TYRO3 mRNA expression was observed in positive sites of ZIKV positive placentas in comparison to negative sites. The basis of this downregulation can help to understand how ZIKV persists in placental tissue during pregnancy.