Identification of divergent placental profiles in clinically distinct pregnancy complications revealed by the transcriptome

• DOI: 10.1016/j.placenta.2024.07.008
• Publication Date: 2024-07-22T07:14:55Z
• Authors: Camille Couture; Maxime Caron; Pascal St-Onge; Marie-Eve Brien; Daniel Sinnett; Dorothée Dal Soglio; Sylvie Girard
• Keywords: Intrauterine growth restriction

Pregnancy complications, including preeclampsia (PE), preterm birth (PTB), and intra-uterine growth restriction (IUGR) have individually been associated with inflammation but the combined comparative analysis of their placental profiles at transcriptomic histological levels is lacking. Bulk RNA-sequencing human biopsies from uncomplicated term pregnancies (CTL) complicated early-onset (EO), late-onset (LO) PE, as well PTB IUGR were used to characterize individual molecular profiles. We also applied immune-cell-specific cellular deconvolution address local immune cell compositions analyzed lesions by histology further these complications. Transcriptome revealed that clinically distinct complications differentiated themselves in unique ways compared CTLs. Only TMEM136 was commonly modulated. Compared CTLs, we found most distinct, LOPE being least distinct. differently enhanced inflammatory pathways, where had general responses activation. This reflected profile for only, whereas structural elevated all Placental additionally corresponding enhancement biological processes. observed having co-complications, particularly or without IUGR, impacted transcriptomes. Lastly, uncovered shared features among Overall, provide evidence pregnancy are not only clinical manifestations profiles, which could be leveraged understand underlying mechanisms offer therapeutic targets.