Electrosprayed Poly-butyl-succinate microparticles for sustained release of Ciprofloxacin as an antimicrobial delivery system

• DOI: 10.1016/j.powtec.2023.119152
• Publication Date: 2023-11-17T04:18:36Z
• Authors: Giorgia Puleo; Francesca Terracina; Valentina Catania; Sergio Sciré; Domenico Schillaci; Mariano Licciardi
• Keywords: Biocompatibility

The increasingly complex treatment of bacterial infections, and its relevance in the clinical setting, requires development innovative strategies to improve patients' quality life. In this context, polymeric microparticles represents a versatile drug delivery system (DDS) capable improving antibiotics' efficacy treatments, by loading drugs while modifying their release profile. study we aimed produce electrospraying using Poly-Butyl-Succinate (PBS), biodegradable biocompatible polyester. This easy-to-use technique enabled incorporation poorly water-soluble Ciprofloxacin (CPX) into polymer matrix. CPX is fluoroquinolone antibiotic, inhibiting replication effectively treating various infections. PBS well-known water-insoluble with tuneable chemical-physical properties, also used for tissue regeneration wound healing applications. An ex-vivo permeation on porcine skin, serving as model human was performed assess potential enhancement permeation. were characterized means different techniques (SEM-EDX, XRD, ATR-FTIR, DSC), degradation rate tested DPBS plasma. Moreover, as-produced DDS sustained several days, which proved effective against S. aureus P. aeruginosa reference group bacteria skin microbiota often involved pathological processes that make wounds chronic difficult heal. MIC MBC assays conducted culture media. Effective antibacterial activity observed, along inhibition biofilm formation at sub-MIC concentrations.