Dietary supplementation with vitamin C ameliorates the adverse effects of Salmonella Enteritidis-challenge in broilers by shaping intestinal microbiota

• DOI: 10.1016/j.psj.2020.03.062
• Publication Date: 2020-04-24T17:29:02Z
• Authors: Liping Gan; Hao Fan; Tahir Mahmood; Yuming Guo
• Keywords: Cecum; Jejunum

Salmonella Enteritidis (SE) infection is not only a leading cause of poor production performance and compromised animal welfare in broilers but also potential threat to public health. Two experiments were conducted evaluate the effects dietary supplemental vitamin C (VC) on SE challenged-broilers. In experiment 1, one hundred eighty 1-day-old Arbor Acre randomly allocated into 3 treatments, with 0, 500, or 1,000 mg/kg VC included diet. 2, at 0 500 mg/kg, without challenge was applied 2 × factorial arrangement 6 randomized complete blocks. addition increased BW infectious bursal disease (IBD) titer 35 D (P < 0.05), whereas had no IBD > 0.05) compared control group. depressed 11 21 0.05 P = 0.088, respectively), mortality hepatic bacterial translocation D. Further, resulted lower villus height jejunum, microbial richness, diversity, higher abundance Enterobacteriaceae cecum 0.05). Importantly, supplementation both respectively) enhanced intestinal health by improving morphology structure as indicated cecal richness Firmicutes Bacteroidetes ratio, while addition, birds fed diet significantly jejunal secretory immunoglobulin A levels, T lymphocytes stimulation index, serum total antioxidant capability groups conclusion, induced broilers. However, ameliorated SE-caused damage health, partly mediated shaping microbiota.