Research Note: Analysis of immune responses in broilers after vaccination against Campylobacter jejuni

• DOI: 10.1016/j.psj.2023.102510
• Publication Date: 2023-01-20T07:35:16Z
• Authors: Noémie Gloanec; Daniel Dory; Ségolène Quesne; Véronique Béven; Typhaine Poezevara; Michel Amelot; Marianne Chemaly; Muriel Guyard-Nic...
• Keywords: Flagellin; Cecum; TLR5; Humoral immunity

Campylobacter infections traced mainly to poultry products are major bacterial foodborne zoonoses. Among the many control strategies evaluated at primary level reduce these infections, vaccination could be a solution, but no effective vaccines available date. A better understanding of immune mechanisms involved in protection against would helpful for designing novel vaccine strategies. The present study was designed analyze more depth responses developed broilers order potentially identify which parameters may important establishing by comparing obtained here with those previous performed on vaccinated specific-pathogen-free Leghorn chickens that presented partial reduction after experimental challenge. colonization different time points over 40 d rearing, measuring specific IgY levels serum and IgA antibodies bile reflecting systemic mucosal humoral respectively relative expressions 9 cecal marker genes (cytokines antimicrobial peptides), reflect innate cellular responses. Despite cecum, response characterized production anti-flagellin observed, addition upregulation peptide avian β-defensin (AvBD) 12 gene expression cecum compared placebo group. However, as well other cytokines studied underexpressed group or similar both groups.