Pathogenicity of duck circovirus 1 in experimentally infected specific pathogen-free ducks

• DOI: 10.1016/j.psj.2023.103301
• Publication Date: 2023-11-19T03:02:57Z
• Authors: Xuezhi Cui; Yudong Zhu; Qiong Wu; Dalin He; Mingtian Mao; Feng Wei; Bingrong Wu; Siming Zhu; Yitong Cui; Qinghai Han; Dongping Wang; Mian Wu; Yubo Zhao; Hui Ren; Xinhui Wei; Meijuan Zhang; Youxiang Diao; Yi Tang
• Keywords: Circovirus; Specific-pathogen-free; Flock

Ducks infected with duck circovirus (DuCV) show symptoms such as feather loss, growth retardation and low body weight in the flock. The virus induces immunosuppression increases prevalence of infection other pathogens. However, most studies on were focused co-infection, fewer had been conducted pathogenicity alone. aim present study was to investigate pathogenesis DuCV-1 experimentally specific pathogen-free ducks. In this study, we sequenced whole genome a strain identified genotype DuCV-1b. This named SDLH(OR567883). Animal experiments then conducted, wherein ducks by mucosal injection abdominal injection. Infected sampled for four consecutive weeks after showed dwarfism. We further examined replication highest titers two groups found liver spleen, different results routes infection. Pathological sections organs made it that spleen damaged DuCV-1. conclusion, our experimental indicate can infect individually cause widespread organ damage