Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study

• DOI: 10.1016/j.psychres.2023.115184
• Publication Date: 2023-03-28T15:15:33Z
• Authors: Laura Fusar-Poli; Thanavadee Prachason; Gamze Erzin; Lotta-Katrin Pries; Natascia Brondino; Pierluigi Politi; Philippe Delespaul; Gunter Kenis; Jurjen J Luykx; Bochao D Lin; Alexander L Richards; Berna Akdede; Tolga Binbay; Vesile Altınyazar; Berna Yalınçetin; Güvem Gümüş-Akay; Burçin Cihan; Haldun Soygür; Halis Ulaş; Eylem Şahin Canku...; Semra Ulusoy Kaymak; Marina M Mihaljevic; Sanja Andric-Petr...; Tijana Mirjanic; Miguel Bernardo; Gisela Mezquida; Silvia Amoretti; Julio Bobes; Pilar A Saiz; Maria Paz García-...; Julio Sanjuan; Maria Jose Escarti; José Luis Santos; Estela Jiménez-López; Manuel Arrojo; Angel Carracedo; Gonzalo López; Javier González-P...; Mara Parellada; Nadja P Maric; Cem Atbaşoğlu; Alp Üçok; Köksal Alptekin; Meram Can Saka; Celso Arango; Michael O'Donovan; Jim van Os; Bart PF Rutten; Sinan Guloksuz
• Keywords: Neurocognitive; Exposome; Association (psychology)

People with schizophrenia spectrum disorders (SSD) frequently present cognitive impairments. Here, we investigated whether the exposome score for (ES-SCZ) - a cumulative environmental exposure was associated impairments of neurocognition, social cognition, and perception in patients SSD, their unaffected siblings, healthy controls.This cross-sectional sample consisted 1200 patients, 1371 1564 controls. Neurocognition, were assesed using short version Wechsler Adult Intelligence Scale-Third Edition (WAIS-III), Degraded Facial Affect Recognition Task (DFAR), Benton Test (BFR), respectively. Regression models used to analyze association between ES-SCZ domains each group.There no statistically significant associations SSD. negatively T-score cognition siblings (B=-0.40, 95% CI -0.76 -0.03) controls (B=-0.63, -1.06 -0.21). Additionally, positively DFAR-total (B=0.83, 0.26 1.40). Sensitivity analyses excluding cannabis use history from largely confirmed main findings.Longitudinal cohorts may elucidate how exposures influence onset course trans-syndromic psychosis spectrum.