COPD phenotypes by computed tomography and ventilatory response to exercise

• DOI: 10.1016/j.pulmoe.2022.01.002
• Publication Date: 2022-02-01T21:27:32Z
• Authors: S. Rodrigues Sousa; J. Nunes Caldeira; C. Rodrigues
• Keywords: Hounsfield scale

Computed tomographic (CT) phenotypic patterns of chronic obstructive pulmonary disease (COPD) identify different clinical features disease. The impact these variables on the physiological response to exercise has been focus a great deal research as it allows more individualized approaches. aim our study was evaluate relationships between CT phenotyping subjects with COPD and ventilatory during cardiopulmonary testing (CPET). Subjects were classified into four phenotypes based metrics emphysema (low attenuation area less than threshold -950 Hounsfield [%LAA-950]) airwall thickness (bronchial wall percentage [%WA]). Eighty patients (78.8% males, median age 65±11.3 years) enrolled in study. Based phenotype, 25 (31.3%) normal, 27 (33.8%) air dominant, 17 (21.3%) dominant 11 (13.8%) mixed type. showed highest equivalent for carbon dioxide (VE/VCO2) VE/VCO2 slope (p<0,05). In all phenotypes, %LAA positive correlated (r = 0.437, p 0.006 r 0.503, p<0.001, respectively). %WA also correlation 0.541, p<0.001 0.299, 0.033, multivariate regression models, after adjustment age, BMI, sex FEV1, only independent predictor (β 0.343, SE 0.147, 95% CI 0.009/0.610, 0.044 β 0.496, 0.081, 0.130/0.455, 0.001, Emphysema (%LAA) airways (%WA) had strong characteristics mild moderate COPD. particular, seemed play an important role slope. These results suggested that may help predicting