Multimodality imaging approach in a case of vascular toxicity caused by cabozantinib

• DOI: 10.1016/j.radcr.2023.09.062
• Publication Date: 2023-10-21T16:05:34Z
• Authors: Georgios Benetos; Angeliki Vakka; Vasiliki Kalogera; Eirini Solomou; Lefki Nikolopoulou; Vasiliki Katsi; Maria Drakopoulou; Constantinos Tsio...; Konstantinos Tout...
• Keywords: Coronary vasospasm; Cabozantinib

Vascular toxicity caused by cancer treatment can present as vasospasm, arterial thrombosis, and accelerated atherosclerosis. We report a case of 60-year-old man with metastatic renal cell carcinoma under cabozantinib for 3 years who presented to the hospital relapsing episodes rest angina. Due presence ST depression in 12-lead electrocardiogram elevated troponin, non-ST-segment elevation myocardial infarction was suspected. The patient underwent invasive coronary angiography, which revealed extended artery spasm, it subsided totally after nitrate administration. One year later, again at cardio-oncology outpatient clinic, reporting angina during previous month. Coronary computed tomography angiography performed, 2 subsequent 70%-99% stenosis OM1. To our knowledge, this is first treated presenting spasm atherosclerosis, multimodality imaging approach followed.