Variations in folate prescriptions for patients with the MTHFR genetic polymorphisms: A case series study

• DOI: 10.1016/j.rcsop.2023.100277
• Publication Date: 2023-05-08T13:06:08Z
• Authors: Carolyn Jane Ledo...; Janet Schloss; Amie Steel
• Keywords: Folinic acid; Metoclopramide

Over 48.5 million couples are reported with infertility worldwide. Health policy recommends folic acid in women of childbearing age, particularly preconception and pregnancy which results purchasing over-the-counter prenatal multivitamins containing through pharmacies other retail outlets. Emerging studies investigating whether forms supplemental folate more suitable, for those methylenetetrahydrofolate reductase (MTHFR) polymorphisms. This case series aimed to document variations dosage prescribed by Australian practitioners patients diagnosed MTHFR polymorphisms.Australian were invited complete a retrospective report form that presented unexplained infertility. documented the dose prescribing their patient polymorphisms, together fertility history.Six submitted information 12 All had been advised practitioner remove 5-methyltetrahydrofolate (5-MTHF) or combination 5-MTHF folinic acid, at higher doses than recommended (mean daily maximum dose: 2325μg). Eleven conceived within treatment period (average one year) ten as having live birth.This has highlighted clinical practices vary from recommendations policy. Further research is required verify importance prescriptions polymorphisms how may need change depending on these direct relevance pharmacy level, specifically pharmacists assistants.