Exceptional human longevity is associated with a specific plasma phenotype of ether lipids

• DOI: 10.1016/j.redox.2019.101127
• Publication Date: 2019-01-30T05:06:07Z
• Authors: I. Pradas; M. Jové; K. Huynh; J. Puig; M. Ingles; C. Borras; J. Viña; PJ. Meikle; R. Pamplona
• Keywords: Phosphatidylethanolamine; Centenarian

A lipid profile resistant to oxidative damage is an inherent trait associated with animal lifespan. However, there a lack of lipidomic studies on human longevity. Here we use mass spectrometry based technologies detect and quantify 137 ether lipids define phenotype healthy humans exceptional Ether were chosen because their antioxidant properties ability modulate stress. Our results demonstrate that specific signature can be obtained the centenarian state. This comprises higher level alkyl forms derived from phosphatidylcholine shorter number carbon atoms double bonds; decreased content in alkenyl phosphatidylethanolamine longer chain length bonds. compositional pattern suggests centenarians are more peroxidation, expresses optimized feature These keeping free radical theory aging.