Plasmalogen attenuates the development of hepatic steatosis and cognitive deficit through mechanism involving p75NTR inhibition

• DOI: 10.1016/j.redox.2021.102002
• Publication Date: 2021-05-07T16:50:48Z
• Authors: Yanjun Liu; Peixu Cong; Tao Zhang; Rui Wang; Xiaoxu Wang; Junyi Liu; Xinceng Wang; Jie Xu; Yuming Wang; Jingfeng Wang; Changhu Xue
• Keywords: Steatosis; Steatohepatitis; Plasmalogen

Emerging evidence suggests that the reduction of ethanolamine plasmalogen (PlsEtn) is associated with in Alzheimer's disease and metabolic diseases. However, mechanistic bases for PlsEtn on these diseases are not well understood. Plasmalogens primarily synthesized liver enriched brain. To this end, present study sought to investigate potential role steatohepatitis memory impairments its underlying mechanism. Here we show peroxisome dysfunction impairment synthesis pathway occurs both hippocampus liver, resulting decrease level APP/PS1 mice HFD-fed mice. shGNPAT induced deficiency hepatocytes induces p75NTR enhancement leading decreased lipolysis activity, thereby exacerbating steatosis. Moreover, brain, administration appears only improve steatosis but also prevent through restoration TrkA/p75NTR balance. Together, our findings reveal a molecular insight into preventive modulation against via inhibition.