Unraveling the parahormetic mechanism underlying the health-protecting effects of grapeseed procyanidins

• DOI: 10.1016/j.redox.2023.102981
• Publication Date: 2023-12-07T17:32:38Z
• Authors: G. Baron; A. Altomare; L. Della Vedova; F. Gado; O. Quagliano; S. Casati; N. Tosi; L. Bresciani; D. Del Rio; G. Roda; A. D'Amato; C. Lammi; A. Macorano; S. Vittorio; G. Vistoli; L. Fumagalli; M. Carini; A. Leone; M. Marino; C. Del Bo’; G. Miotto; F. Ursini; P. Morazzoni; G. Aldini
• Keywords: (Poly)Phenols; Medicine (General); 0303 health sciences; (Poly)Phenols; 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone; Anti-inflammatory and antioxidant activities; Keap1; Metabolism; Microbiota; NFκB; Nrf2; Proanthocyanidins;; QH301-705.5; Microbiota; Anti-inflammatory and antioxidant activities; 03 medical and health sciences; Metabolism; R5-920; (Poly)Phenols; 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone; Anti-inflammatory and antioxidant activities; Keap1; Metabolism; Microbiota; NFκB; Nrf2; Proanthocyanidins; 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone; Proanthocyanidins; Biology (General); Research Paper

Proanthocyanidins (PACs), the predominant constituents within Grape Seed Extract (GSE), are intricate compounds composed of interconnected flavan-3-ol units. Renowned for their health-affirming properties, PACs offer a shield against spectrum inflammation associated diseases, such as diabetes, obesity, degenerations and possibly cancer. While monomeric dimeric undergo some absorption gastrointestinal tract, larger oligomeric polymeric counterparts not bioavailable. However, higher molecular weight engage with colonic microbiota, fostering production bioavailable metabolites that metabolic processes, culminating in emergence bioactive agents capable modulating physiological processes. Within this investigation, GSE enriched was employed to explore detail impact. Through comprehensive analysis, present study unequivocally verified gastrointestinal-mediated transformation medium high PACs, thereby establishing bioaccessibility principal catabolite termed 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone (VL). Notably, our findings, encompassing cell biology, chemistry proteomics, converge proposal notion capacity VL activate, upon oxidation corresponding quinone, nuclear factor E2-related 2 (Nrf2) pathway—an process incites cellular defenses mitigates stress-induced responses, challenge brought by TNFα. This mechanistic paradigm seamlessly aligns concept para-hormesis, ultimately orchestrating resilience stress preservation redox equilibrium homeostasis benchmarks health.